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KMID : 0980720070260010059
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Keimyung Medical Journal
2007 Volume.26 No. 1 p.59 ~ p.65
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CT-guided High-dose Percutaneous Ethanol Injection Therapy for Treatment of Bone Metastasis of Hepatocellular Carcinoma: Preliminary Experience
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Kwon Jung-Hyuk
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Abstract
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With the improved prognosis of patients with hepatocellular carcinoma (HCC), the likelihood of diagnosing bone metastasis has increased. We evaluated the feasibility and safety of percutaneous ethanol injection (PEI) therapy for treatment of bone metastasis of HCC. Between March 2006 and April 2007, computed tomography (CT)-guided high-dose PEI therapy was performed for six bone metastases (two ilium, one clavicle, one lumbar spine, one pubic bone, and one ischium) in six patients with HCC. Follow-up CT scan was performed at 3-month intervals to assess local recurrence. Feasibility of PEI therapy and complications associated with PEI therapy were evaluated. A total of 12 sessions of PEI were performed for six bone metastases. Apparent tumor necrosis was noted at CT scan performed 1 day and 1 month after PEI therapy in all six bone metastases. During CT follow-up (range, 1 to 13 months; mean, 6.2 months), local recurrence was not seen in all bone metastases. We did not experience any complication except pain or fever during and/or after the procedure. PEI therapy was successfully performed for six bone metastases in six patients with HCC. This therapy seems to be feasible and safe for treatment of bone metastasis of HCC.
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KEYWORD
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Alcohol ablation, Bone metastasis, Hepatocellular carcinoma
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